Abstract: The problem of tuberculosis has not lost its relevance; the groups at the highest risk of developing tuberculosis should be of the greatest interest for reducing the incidence of tuberculosis. Aim. To determine the contribution of social and medical factors in the development of tuberculosis in patients with chronic obstructive pulmonary disease and to determine the possibility of influencing them in order to prevent tuberculosis. Material and methods. The study included 204 patients with newly diagnosed tuberculosis and chronic obstructive pulmonary disease, of whom 180 were men (88,2%), mean age (Me 25;75) was 48,45 (38; 57) years. Factor analysis was used as a mathematical instrument, the main task of which is to find latent factors describing latent processes of the phenomenon of interest. Fifteen parameters determining the degree of tuberculosis development in patients with chronic obstructive pulmonary disease were taken as the initial parameters of factor study. Factor analysis made it possible to determine six significant factors. Total factor variance amounted to 76,5% of the contribution of all factors, which testifies to sufficient adequacy of the developed model. Results and discussion. The first factor, namely tobacco addiction, was classified as manageable medico-social one, its contribution to tuberculosis development was 27,6%, it was distributed between the fact of smoking, smoking experience, intensity of smoking, index of smoking (number of cigarettes per day×12), history of smoking (number of cigarettes per day×years of smoking/20). The second factor, which was social and demographic, with a contribution of 12,6%, included marital status and presence of children. The third factor, medico-social, with a 12,4% contribution to the development of tuberculosis, involved dependence on narcotic drugs and the presence of HIV infection. The fourth factor indicated an association between male gender and greater likelihood of developing tuberculosis, with a contribution of 8,1%. The fifth factor, age, with a contribution of 8,0% to the development of tuberculosis in a patient with chronic obstructive pulmonary disease. The sixth factor, social, with a contribution of 7,7%, included availability of housing and living conditions. Conclusion. Risk groups for tuberculosis development among patients with chronic obstructive pulmonary disease are elderly men, socially vulnerable - those who do not have their own homes, live in poor social and hygienic conditions, do not have families and children, have HIV infection, injecting drug users, smokers with a long history and high smoking intensity. Prevention of tuberculosis in patients with chronic obstructive pulmonary disease should have a medical and social nature and include measures to combat tobacco and drug addiction, as well as increasing adherence to antiretroviral therapy in patients with HIV infection. © 2021, LLC IMC Modern Clinical Medicine. All rights reserved.

Cite: Bagisheva N.V. , Mordyk A.V. , Nesterova K.I. , Goltyapin V.V. , Aroyan A.R. , Rudenko S.A. , Shirinskaya N.V.
Factor analysis of socio-demographic preconditions for tuberculosis development in patients with chronic obstructive pulmonary disease
Вестник современной клинической медицины. 2021. V.14. N1. P.7-15. DOI: 10.20969/VSKM.2021.14(1).7-15 Scopus OpenAlex

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Scopus:	2-s2.0-85109635203
OpenAlex:	W3137066802

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