Numerical Simulation of T-Lymphocyte Population Dynamics in a Lymph Node Full article
| Journal |
Journal of Applied and Industrial Mathematics
ISSN: 1990-4789 , E-ISSN: 1990-4797 |
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| Output data | Year: 2022, Volume: 16, Number: 4, Pages: 737-750 Pages count : 14 DOI: 10.1134/S1990478922040147 | ||||||
| Tags | population of CD4+ T-lymphocytes, homeostasis, lymph node, mathematical model, model well-posedness, computational experiment, HIV-1 infection | ||||||
| Authors |
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| Affiliations |
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Funding (2)
| 1 | Russian Science Foundation | 18-11-00171 |
| 2 | Московский центр фундаментальной и прикладной математики | 075-15-2022-286 |
Abstract:
A mathematical model is presented that describes the dynamics of the population of CD4 T-lymphocytes in a single lymph node. The model is based on a high-dimensional system of nonlinear delay differential equations supplemented with initial data. The equations of the model are given, and their well-posedness is investigated. The results of computational experiments with the model illustrating the characteristic cell population dynamics under the conditions of antigen-specific stimulation of the cell reproduction process for cells of various types are presented.
Cite:
Pertsev N.V.
, Bocharov G.A.
, Loginov K.K.
Numerical Simulation of T-Lymphocyte Population Dynamics in a Lymph Node
Journal of Applied and Industrial Mathematics. 2022. V.16. N4. P.737-750. DOI: 10.1134/S1990478922040147 Scopus РИНЦ OpenAlex
Numerical Simulation of T-Lymphocyte Population Dynamics in a Lymph Node
Journal of Applied and Industrial Mathematics. 2022. V.16. N4. P.737-750. DOI: 10.1134/S1990478922040147 Scopus РИНЦ OpenAlex
Original:
Перцев Н.В.
, Бочаров Г.А.
, Логинов К.К.
Численное моделирование динамики популяции Т-лимфоцитов в лимфоузле
Сибирский журнал индустриальной математики. 2022. Т.25. №4. С.136-152. DOI: 10.33048/SIBJIM.2022.25.411 РИНЦ
Численное моделирование динамики популяции Т-лимфоцитов в лимфоузле
Сибирский журнал индустриальной математики. 2022. Т.25. №4. С.136-152. DOI: 10.33048/SIBJIM.2022.25.411 РИНЦ
Dates:
| Submitted: | Jun 6, 2022 |
| Accepted: | Jun 22, 2022 |
| Published print: | Mar 6, 2023 |
| Published online: | Mar 6, 2023 |
Identifiers:
| Scopus: | 2-s2.0-85150196403 |
| Elibrary: | 58788365 |
| OpenAlex: | W4323344563 |