Mathematical Modeling of HIV Replicaton and the Response of the Interferon System

Mathematical Modeling of HIV Replicaton and the Response of the Interferon System Full article

Journal

Molecular Biology
ISSN: 0026-8933 , E-ISSN: 1608-3245

Output data

Year: 2023, Volume: 57, Number: 4, Pages: 700-713 Pages count : 14 DOI: 10.1134/s0026893323040076

Tags

mathematical model, human immunodeficiency virus, replication, accessory proteins, type I interferon, interferon response, interferon-stimulated proteins

Authors

Gainova I.A. ¹ , Soboleva A.E. ² , Grebennikov Dmitry ^3,4 , Bocharov Gennady ^3,4

Affiliations

1	Sobolev Institute of Mathematics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
2	Moscow Institute of Physics and Technology (National Research University, Dolgoprudny, Russia
3	Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia
4	Marchuk Institute of Numerical Mathematics, Russian Academy of Sciences, Moscow, Russia

Funding (2)

1	Sobolev Institute of Mathematics	FWNF-2022-0015
2	Russian Foundation for Basic Research	20-01-00352

Developing physiologically meaningful mathematical models that describe multilevel regulation in a complex network of immune processes, in particular, of the system of interferon-regulated virus production processes, is a fundamental scientific problem, within the framework of an interdisciplinary systems approach to research in immunology. Here, we have presented a detailed high-dimensional model describing HIV (human immunodeficiency virus) replication, the response of type I interferon (IFN) to the virus infection of the cell, and suppression of the action of IFN-induced proteins by HIV accessory proteins. As a result, this model includes interactions of all three processes for the first time. The mathematical model is a system of 37 nonlinear ordinary differential equations including 78 parameters. Importantly, the model describes not only the processes of the IFN response of the cell to virus infection, but also the mechanisms used by the virus to prevent effects of the IFN system.

Gainova I.A. , Soboleva A.E. , Grebennikov D. , Bocharov G.
Mathematical Modeling of HIV Replicaton and the Response of the Interferon System
Molecular Biology. 2023. V.57. N4. P.700-713. DOI: 10.1134/s0026893323040076 WOS Scopus РИНЦ OpenAlex

Гайнова И.А. , Соболева А.Е. , Гребенников Д.С. , Бочаров Г.А.
Математическое моделирование процесса репликации ВИЧ и ответа системы интерферона
Молекулярная биология. 2023. Т.57. №4. С.692-705. DOI: 10.31857/S0026898423040080 Scopus РИНЦ OpenAlex

Submitted:	Aug 9, 2022
Accepted:	Dec 24, 2022
Published print:	Aug 8, 2023
Published online:	Aug 8, 2023

Web of science:	WOS:001044476200014
Scopus:	2-s2.0-85168278449
Elibrary:	62771036
OpenAlex:	W4385654971

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