Levosimendan in patients with low-cardiac-output syndrome after cardiac surgery: Substudy of the multicenter randomized CHEETAH trial | Sciact - Система учета научной деятельности ИМ СО РАН

Levosimendan in patients with low-cardiac-output syndrome after cardiac surgery: Substudy of the multicenter randomized CHEETAH trial Научная публикация

Журнал

Journal of Cardiothoracic and Vascular Anesthesia
ISSN: 1053-0770 , E-ISSN: 1532-8422

Вых. Данные

Год: 2025, Том: 39, Номер: 1, Страницы: 151-161 Страниц : 11 DOI: 10.1053/j.jvca.2024.10.003

Ключевые слова

levosimendan; cardiac surgery; low cardiac output syndrome; cardiopulmonary bypass

Авторы

Boboshko Vladimir ¹ , Lomivorotov Vladimir ² , Ruzankin Pavel ³ , Khrushchev Sergey ⁴ , Lomivorotova Liudmila ¹ , Monaco Fabrizio ⁵ , Calabrò Maria Grazia ⁵ , Comis Marco ⁶ , Bove Tiziana ^7,8 , Pisano Antonio ⁸ , Belletti Alessandro ⁵

Организации

1	Department of Anesthesiology and Intensive Care, E. Meshalkin National Medical Research Center, Novosibirsk, Russia. Electronic address: vaboboshko@gmail.com.
2	Department of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA.
3	Department of Mathematics and Mechanics, Novosibirsk State University, Novosibirsk, Russia;
4	Sobolev Institute of Mathematics, Novosibirsk, Russia.
5	Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
6	Cardiac and Vascular Department, Ospedale Mauriziano Umberto I, Torino, Italy.
7	Department of Medicine (DMED), University of Udine, Italy; Department of Emergency "Santa Maria della Misericordia", Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine University Hospital, Udine, Italy.
8	Cardiac Anesthesia and ICU, AORN "Dei Colli", Monaldi Hospital, Naples, Italy.

Информация о финансировании (1)

Институт математики им. С.Л. Соболева СО РАН

FWNF-2024-0001

Objective: To test the hypothesis that levosimendan administration in patients with low cardiac output syndrome after cardiac surgery is associated with improved long-term (5-year follow-up) outcomes. Design: Single-center subanalysis of the multicenter randomized CHEETAH trial. Setting: Cardiac surgery department of a tertiary hospital. Participants: A total of 134 adult patients requiring hemodynamic support for a cardiac index <2.5 L/min/m2 after cardiac surgery with cardiopulmonary bypass (CPB). Interventions: Patients were randomized (1:1 ratio) to receive levosimendan (continuous infusion with a starting dose of 0.05 μg/kg/min) or placebo, in addition to standard inotropic care. Measurements and Main Results: The primary endpoint was long-term mortality (1-5 years) after randomization. Secondary outcomes were hemodynamic parameters, need for inotropic support, acute kidney injury (AKI), need for renal replacement therapy, duration of mechanical ventilation, intensive care unit (ICU) and hospital stay, and 30-day mortality. No significant between-group difference in long-term mortality (5 years) was observed (hazard ratio, 1.59; 95% confidence interval, 0.81 to 3.11; p = 0.17). There were no significant differences in secondary outcomes, except for the difference in the mean pulmonary artery pressure at 4 to 6 hours after randomization, which was lower in the levosimendan group compared to the placebo group (median, 24 [interquartile range (IQR), 21.8-28] mmHg vs 26 [IQR, 22.2-33] mmHg; p = 0.019). Conclusions: Among patients requiring hemodynamic support after cardiac surgery with CPB, perioperative levosimendan infusion did not affect long-term survival (1-5 years) compared with placebo. Levosimendan also had no effect on major clinical outcomes such as AKI, ICU stay, hospital stay, and 30-day mortality

Boboshko V. , Lomivorotov V. , Ruzankin P. , Khrushchev S. , Lomivorotova L. , Monaco F. , Calabrò M.G. , Comis M. , Bove T. , Pisano A. , Belletti A.
Levosimendan in patients with low-cardiac-output syndrome after cardiac surgery: Substudy of the multicenter randomized CHEETAH trial
Journal of Cardiothoracic and Vascular Anesthesia. 2025. V.39. N1. P.151-161. DOI: 10.1053/j.jvca.2024.10.003 WOS Scopus РИНЦ OpenAlex

Опубликована online:	10 окт. 2024 г.
Опубликована в печати:	9 янв. 2025 г.

Web of science:	WOS:001410989800001
Scopus:	2-s2.0-85208051818
РИНЦ:	79266382
OpenAlex:	W4403287613

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